It is very important that your doctor check your or your child's progress while using this medicine, especially within the first 24 to 72 hours of treatment. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to take it. Blood and urine tests may be needed to check for unwanted effects.
It is against the law and dangerous for anyone else to use your medicine. Keep your unused tablets in a safe and secure place. People who are addicted to drugs might want to steal this medicine. This medicine will add to the effects of alcohol and other CNS depressants medicines that can make you drowsy or less alert.
Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics numbing medicines , including some dental anesthetics. Also, there may be a greater risk of liver damage if you drink three or more alcoholic beverages while you are taking acetaminophen.
Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine. This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. If you think you or someone else may have taken an overdose of this medicine, get emergency help at once.
Your doctor may also give naloxone to treat an overdose. Signs of an overdose include: cold, clammy skin, coughing that sometimes produces a pink frothy sputum, dark urine, difficult or trouble breathing, irregular, fast or slow, or shallow breathing, nausea, vomiting, pain in the upper stomach, pale or blue lips, fingernails, or skin, pinpoint pupils of the eyes, or yellow eyes or skin. This medicine may cause sleep-related breathing problems eg, sleep apnea, sleep-related hypoxemia.
Your doctor may decrease your dose if you have sleep apnea stop breathing for short periods during sleep while using this medicine. This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.
These could be symptoms of a serious liver problem. This medicine may cause serious skin reactions eg, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness.
This medicine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention.
An opioid might activate the orphan receptor, but it might also activate other receptors that it interacts with. Imagine trying to recreate a musical score by listening to an orchestra perform a piece of music. Understanding what triggers the itching response could help pharmacologists develop an antagonist for this receptor to reduce the itching side effect. In other cases, clinicians may want to induce histamine release, thereby boosting the immune response, as in the case of vaccine adjuvants, where an increased immune response may improve immunity.
These findings suggest there may be a way to do that selectively. The researchers will now move onto other orphans. She also emphasized that work like this would not be possible without the cooperation of a wide variety specialists.
And all of these specialists working together makes findings like these possible. Note: Content may be edited for style and length. Science News. ScienceDaily, 27 March University of North Carolina Health Care.
How do some opioids cause severe itching? One of the very peculiar, interesting side effects is itching. Opioid-induced itching while suppressing pain sensation has been one of the mysteries for a long, long time. We found that this isoform is specifically required for relaying morphine-induced itch. Very interestingly and unexpectedly, we found that this isoform is not involved in morphine analgesia. So this, actually, is the first evidence to show that a morphine isoform has nothing to do with morphine analgesia.
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